Goedert M: Alpha-synuclein and neurodegenerative diseases. Nat Rev Neurosci. 2001, 2 (7): 492-501. 10.1038/35081564.
CAS
PubMed
Google Scholar
Chartier-Harlin MC, Kachergus J, Roumier C, Mouroux V, Douay X, Lincoln S, Levecque C, Larvor L, Andrieux J, Hulihan M, et al: Alpha-synuclein locus duplication as a cause of familial Parkinson's disease. Lancet. 2004, 364 (9440): 1167-1169. 10.1016/S0140-6736(04)17103-1.
CAS
PubMed
Google Scholar
Singleton AB, Farrer M, Johnson J, Singleton A, Hague S, Kachergus J, Hulihan M, Peuralinna T, Dutra A, Nussbaum R, et al: alpha-Synuclein locus triplication causes Parkinson's disease. Science. 2003, 302 (5646): 841-10.1126/science.1090278.
CAS
PubMed
Google Scholar
Krüger R, Kuhn W, Müller T, Woitalla D, Graeber M, Kosel S, Przuntek H, Epplen JT, Schols L, Riess O: Ala30Pro mutation in the gene encoding α-synuclein in Parkinson's disease. Nat Genet. 1998, 18: 106-108. 10.1038/ng0298-106.
PubMed
Google Scholar
Polymeropoulos MH, Lavedan C, Leroy E, Idle SE, Dehejia A, Dutra A, Pike B, Root H, Rubenstein J, Boyer R, et al: Mutation in the α-Synuclein gene identified in families with Parkinson's disease. Science. 1997, 276: 2045-2047. 10.1126/science.276.5321.2045.
CAS
PubMed
Google Scholar
Zarranz JJ, Alegre J, Gomez-Esteban JC, Lezcano E, Ros R, Ampuero I, Vidal L, Hoenicka J, Rodriguez O, Atares B, et al: The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia. Ann Neurol. 2004, 55 (2): 164-173. 10.1002/ana.10795.
CAS
PubMed
Google Scholar
Irizarry MC, Growdon W, Gomez-Isla T, Newell K, George JM, Clayton DF, Hyman BT: Nigral and cortical Lewy bodies and dystrophic nigral neurites in Parkinson's disease and cortical Lewy body disease contain alpha-synuclein immunoreactivity. J Neuropathol Exp Neurol. 1998, 57 (4): 334-337. 10.1097/00005072-199804000-00005.
CAS
PubMed
Google Scholar
Braak H, Del Tredici K, Rub U, de Vos RA, Jansen Steur EN, Braak E: Staging of brain pathology related to sporadic Parkinson's disease. Neurobiology of aging. 2003, 24 (2): 197-211. 10.1016/S0197-4580(02)00065-9.
PubMed
Google Scholar
Auluck PK, Chan HYE, Trojanowski JQ, Lee VM-Y, Bonini NM: Chaperone suppression of α-synuclein toxicity in a Drosophila model for Parkinson's disease. Science. 2002, 295: 865-868. 10.1126/science.1067389.
CAS
PubMed
Google Scholar
Bodner RA, Outeiro TF, Altmann S, Maxwell MM, Cho SH, Hyman BT, McLean PJ, Young AB, Housman DE, Kazantsev AG: Pharmacological promotion of inclusion formation: a therapeutic approach for Huntington's and Parkinson's diseases. Proc Natl Acad Sci U S A. 2006, 103 (11): 4246-4251. 10.1073/pnas.0511256103.
PubMed Central
CAS
PubMed
Google Scholar
Bucciantini M, Calloni G, Chiti F, Formigli L, Nosi D, Dobson CM, Stefani M: Prefibrillar amyloid protein aggregates share common features of cytotoxicity. J Biol Chem. 2004, 279 (30): 31374-31382. 10.1074/jbc.M400348200.
CAS
PubMed
Google Scholar
El-Agnaf OM, Salem SA, Paleologou KE, Curran MD, Gibson MJ, Court JA, Schlossmacher MG, Allsop D: Detection of oligomeric forms of alpha-synuclein protein in human plasma as a potential biomarker for Parkinson's disease. FASEB J. 2006, 20 (3): 419-425. 10.1096/fj.03-1449com.
CAS
PubMed
Google Scholar
Kayed R, Head E, Thompson JL, McIntire TM, Milton SC, Cotman CW, Glabe CG: Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science. 2003, 300 (5618): 486-489. 10.1126/science.1079469.
CAS
PubMed
Google Scholar
Lashuel HA, Petre BM, Wall J, Simon M, Nowak RJ, Walz T, Lansbury PT: Alpha-synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils. J Mol Biol. 2002, 322 (5): 1089-1102. 10.1016/S0022-2836(02)00735-0.
CAS
PubMed
Google Scholar
Masliah E, Rockenstein E, Veinbergs I, Mallory M, Hashimoto M, Takeda A, Sagara Y, Sisk A, Mucke L: Dopaminergic loss and inclusion body formation in α-synuclein mice: Implications for neurodegenerative disorders. Science. 2000, 287: 1265-1269. 10.1126/science.287.5456.1265.
CAS
PubMed
Google Scholar
Desplats P, Lee HJ, Bae EJ, Patrick C, Rockenstein E, Crews L, Spencer B, Masliah E, Lee SJ: Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein. Proc Natl Acad Sci U S A. 2009, 106 (31): 13010-13015. 10.1073/pnas.0903691106.
PubMed Central
CAS
PubMed
Google Scholar
Danzer KM, Ruf WP, Putcha P, Joyner D, Hashimoto T, Glabe C, Hyman BT, McLean PJ: Heat Shock Protein 70 modulates toxic extracellular alpha-synuclein oligomers and rescues trans-synaptic toxicity. FASEB J. 2010, In Press
Google Scholar
Ahn KJ, Paik SR, Chung KC, Kim J: Amino acid sequence motifs and mechanistic features of the membrane translocation of alpha-synuclein. J Neurochem. 2006, 97 (1): 265-279. 10.1111/j.1471-4159.2006.03731.x.
CAS
PubMed
Google Scholar
Danzer KM, Haasen D, Karow AR, Moussaud S, Habeck M, Giese A, Kretzschmar H, Hengerer B, Kostka M: Different species of alpha-synuclein oligomers induce calcium influx and seeding. J Neurosci. 2007, 27 (34): 9220-9232. 10.1523/JNEUROSCI.2617-07.2007.
CAS
PubMed
Google Scholar
Danzer KM, Krebs SK, Wolff M, Birk G, Hengerer B: Seeding induced by alpha-synuclein oligomers provides evidence for spreading of alpha-synuclein pathology. J Neurochem. 2009, 111 (1): 192-201. 10.1111/j.1471-4159.2009.06324.x.
CAS
PubMed
Google Scholar
Lee HJ, Suk JE, Bae EJ, Lee JH, Paik SR, Lee SJ: Assembly-dependent endocytosis and clearance of extracellular alpha-synuclein. Int J Biochem Cell Biol. 2008, 40 (9): 1835-1849. 10.1016/j.biocel.2008.01.017.
CAS
PubMed
Google Scholar
Luk KC, Song C, O'Brien P, Stieber A, Branch JR, Brunden KR, Trojanowski JQ, Lee VM: Exogenous alpha-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells. Proc Natl Acad Sci U S A. 2009, 106 (47): 20051-20056.
PubMed Central
CAS
PubMed
Google Scholar
Emmanouilidou E, Melachroinou K, Roumeliotis T, Garbis SD, Ntzouni M, Margaritis LH, Stefanis L, Vekrellis K: Cell-produced alpha-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival. J Neurosci. 30 (20): 6838-6851.
Alvarez-Erviti L, Seow Y, Schapira AH, Gardiner C, Sargent IL, Wood MJ, Cooper JM: Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission. Neurobiol Dis. 2011, 42 (3): 360-367. 10.1016/j.nbd.2011.01.029.
PubMed Central
CAS
PubMed
Google Scholar
Outeiro TF, Putcha P, Tetzlaff JE, Spoelgen R, Koker M, Carvalho F, Hyman BT, McLean PJ: Formation of toxic oligomeric alpha-synuclein species in living cells. PLoS One. 2008, 3 (4): e1867-10.1371/journal.pone.0001867.
PubMed Central
PubMed
Google Scholar
Putcha P, Danzer KM, Kranich LR, Scott A, Silinski M, Mabbett S, Hicks CD, Veal JM, Steed PM, Hyman BT, et al: Brain permeable small molecule inhibitors of Hsp90 prevent alpha-synucleinoligomer formation and rescue alpha-synuclein-induced toxicity. J Pharmacol Exp Ther. 2009, in press
Google Scholar
Remy I, Michnick SW: A cDNA library functional screening strategy based on fluorescent protein complementation assays to identify novel components of signaling pathways. Methods. 2004, 32 (4): 381-388. 10.1016/j.ymeth.2003.10.011.
CAS
PubMed
Google Scholar
Remy I, Michnick SW: A highly sensitive protein-protein interaction assay based on Gaussia luciferase. Nat Methods. 2006, 3 (12): 977-979. 10.1038/nmeth979.
CAS
PubMed
Google Scholar
St Martin JL, Klucken J, Outeiro TF, Nguyen P, Keller-McGandy C, Cantuti-Castelvetri I, Grammatopoulos TN, Standaert DG, Hyman BT, McLean PJ: Dopaminergic neuron loss and up-regulation of chaperone protein mRNA induced by targeted over-expression of alpha-synuclein in mouse substantia nigra. J Neurochem. 2007, 100 (6): 1449-1457.
CAS
PubMed
Google Scholar
Tetzlaff JE, Putcha P, Outeiro TF, Ivanov A, Berezovska O, Hyman BT, McLean PJ: CHIP targets toxic alpha-Synuclein oligomers for degradation. J Biol Chem. 2008, 283 (26): 17962-17968. 10.1074/jbc.M802283200.
PubMed Central
CAS
PubMed
Google Scholar
Lee HJ, Patel S, Lee SJ: Intravesicular localization and exocytosis of alpha-synuclein and its aggregates. J Neurosci. 2005, 25 (25): 6016-6024. 10.1523/JNEUROSCI.0692-05.2005.
CAS
PubMed
Google Scholar
Mollenhauer B, Cullen V, Kahn I, Krastins B, Outeiro TF, Pepivani I, Ng J, Schulz-Schaeffer W, Kretzschmar HA, McLean PJ, et al: Direct quantification of CSF alpha-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration. Exp Neurol. 2008, 213 (2): 315-325. 10.1016/j.expneurol.2008.06.004.
CAS
PubMed
Google Scholar
Sung JY, Kim J, Paik SR, Park JH, Ahn YS, Chung KC: Induction of neuronal cell death by Rab5A-dependent endocytosis of alpha-synuclein. J Biol Chem. 2001, 276 (29): 27441-27448. 10.1074/jbc.M101318200.
CAS
PubMed
Google Scholar
Fevrier B, Vilette D, Archer F, Loew D, Faigle W, Vidal M, Laude H, Raposo G: Cells release prions in association with exosomes. Proc Natl Acad Sci U S A. 2004, 101 (26): 9683-9688. 10.1073/pnas.0308413101.
PubMed Central
CAS
PubMed
Google Scholar
Thery C, Amigorena S, Raposo G, Clayton A: Isolation and characterization of exosomes from cell culture supernatants and biological fluids. Curr Protoc Cell Biol. 2006, Chapter 3: Unit 3 22-
PubMed
Google Scholar
Escola JM, Kleijmeer MJ, Stoorvogel W, Griffith JM, Yoshie O, Geuze HJ: Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes. J Biol Chem. 1998, 273 (32): 20121-20127. 10.1074/jbc.273.32.20121.
CAS
PubMed
Google Scholar
Simpson RJ, Lim JW, Moritz RL, Mathivanan S: Exosomes: proteomic insights and diagnostic potential. Expert Rev Proteomics. 2009, 6 (3): 267-283. 10.1586/epr.09.17.
CAS
PubMed
Google Scholar
Schultz J, Lorenz P, Gross G, Ibrahim S, Kunz M: MicroRNA let-7b targets important cell cycle molecules in malignant melanoma cells and interferes with anchorage-independent growth. Cell Res. 2008, 18 (5): 549-557. 10.1038/cr.2008.45.
CAS
PubMed
Google Scholar
Taylor DD, Gercel-Taylor C: MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer. Gynecol Oncol. 2008, 110 (1): 13-21. 10.1016/j.ygyno.2008.04.033.
CAS
PubMed
Google Scholar
Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO: Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol. 2007, 9 (6): 654-659. 10.1038/ncb1596.
CAS
PubMed
Google Scholar
Chen XM, Splinter PL, O'Hara SP, LaRusso NF: A cellular micro-RNA, let-7i, regulates Toll-like receptor 4 expression and contributes to cholangiocyte immune responses against Cryptosporidium parvum infection. J Biol Chem. 2007, 282 (39): 28929-28938. 10.1074/jbc.M702633200.
PubMed Central
CAS
PubMed
Google Scholar
Segura MF, Hanniford D, Menendez S, Reavie L, Zou X, Alvarez-Diaz S, Zakrzewski J, Blochin E, Rose A, Bogunovic D, et al: Aberrant miR-182 expression promotes melanoma metastasis by repressing FOXO3 and microphthalmia-associated transcription factor. Proc Natl Acad Sci U S A. 2009, 106 (6): 1814-1819. 10.1073/pnas.0808263106.
PubMed Central
CAS
PubMed
Google Scholar
Weitzel RP, Lesniewski ML, Haviernik P, Kadereit S, Leahy P, Greco NJ, Laughlin MJ: microRNA 184 regulates expression of NFAT1 in umbilical cord blood CD4+ T cells. Blood. 2009, 113 (26): 6648-6657. 10.1182/blood-2008-09-181156.
PubMed Central
CAS
PubMed
Google Scholar
Bentwich I, Avniel A, Karov Y, Aharonov R, Gilad S, Barad O, Barzilai A, Einat P, Einav U, Meiri E, et al: Identification of hundreds of conserved and nonconserved human microRNAs. Nat Genet. 2005, 37 (7): 766-770. 10.1038/ng1590.
CAS
PubMed
Google Scholar
Sewer A, Paul N, Landgraf P, Aravin A, Pfeffer S, Brownstein MJ, Tuschl T, van Nimwegen E, Zavolan M: Identification of clustered microRNAs using an ab initio prediction method. BMC Bioinforma. 2005, 6: 267-10.1186/1471-2105-6-267.
Google Scholar
Huang Q, Gumireddy K, Schrier M, le Sage C, Nagel R, Nair S, Egan DA, Li A, Huang G, Klein-Szanto AJ, et al: The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis. Nat Cell Biol. 2008, 10 (2): 202-210. 10.1038/ncb1681.
CAS
PubMed
Google Scholar
Altuvia Y, Landgraf P, Lithwick G, Elefant N, Pfeffer S, Aravin A, Brownstein MJ, Tuschl T, Margalit H: Clustering and conservation patterns of human microRNAs. Nucleic Acids Res. 2005, 33 (8): 2697-2706. 10.1093/nar/gki567.
PubMed Central
CAS
PubMed
Google Scholar
Kawahara Y, Zinshteyn B, Sethupathy P, Iizasa H, Hatzigeorgiou AG, Nishikura K: Redirection of silencing targets by adenosine-to-inosine editing of miRNAs. Science. 2007, 315 (5815): 1137-1140. 10.1126/science.1138050.
PubMed Central
CAS
PubMed
Google Scholar
Rosa A, Ballarino M, Sorrentino A, Sthandier O, De Angelis FG, Marchioni M, Masella B, Guarini A, Fatica A, Peschle C, et al: The interplay between the master transcription factor PU.1 and miR-424 regulates human monocyte/macrophage differentiation. Proc Natl Acad Sci U S A. 2007, 104 (50): 19849-19854. 10.1073/pnas.0706963104.
PubMed Central
CAS
PubMed
Google Scholar
Wheeler G, Ntounia-Fousara S, Granda B, Rathjen T, Dalmay T: Identification of new central nervous system specific mouse microRNAs. FEBS Lett. 2006, 580 (9): 2195-2200. 10.1016/j.febslet.2006.03.019.
CAS
PubMed
Google Scholar
Ujifuku K, Mitsutake N, Takakura S, Matsuse M, Saenko V, Suzuki K, Hayashi K, Matsuo T, Kamada K, Nagata I, et al: miR-195, miR-455-3p and miR-10a( *) are implicated in acquired temozolomide resistance in glioblastoma multiforme cells. Cancer Lett. 2010, 296 (2): 241-248. 10.1016/j.canlet.2010.04.013.
CAS
PubMed
Google Scholar
Goodarzi H, Elemento O, Tavazoie S: Revealing global regulatory perturbations across human cancers. Mol Cell. 2009, 36 (5): 900-911. 10.1016/j.molcel.2009.11.016.
PubMed Central
CAS
PubMed
Google Scholar
Liu L, Jiang Y, Zhang H, Greenlee AR, Han Z: Overexpressed miR-494 down-regulates PTEN gene expression in cells transformed by anti-benzo(a)pyrene-trans-7,8-dihydrodiol-9,10-epoxide. Life Sci. 86 (5–6): 192-198.
Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, et al: A mammalian microRNA expression atlas based on small RNA library sequencing. Cell. 2007, 129 (7): 1401-1414. 10.1016/j.cell.2007.04.040.
PubMed Central
CAS
PubMed
Google Scholar
Zhu H, Wu H, Liu X, Evans BR, Medina DJ, Liu CG, Yang JM: Role of MicroRNA miR-27a and miR-451 in the regulation of MDR1/P-glycoprotein expression in human cancer cells. Biochem Pharmacol. 2008, 76 (5): 582-588. 10.1016/j.bcp.2008.06.007.
PubMed Central
CAS
PubMed
Google Scholar
Girardot M, Pecquet C, Boukour S, Knoops L, Ferrant A, Vainchenker W, Giraudier S, Constantinescu SN: miR-28 is a thrombopoietin receptor targeting microRNA detected in a fraction of myeloproliferative neoplasm patient platelets. Blood. 2010, 116 (3): 437-445. 10.1182/blood-2008-06-165985.
CAS
PubMed
Google Scholar
Tazawa H, Tsuchiya N, Izumiya M, Nakagama H: Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells. Proc Natl Acad Sci U S A. 2007, 104 (39): 15472-15477. 10.1073/pnas.0707351104.
PubMed Central
CAS
PubMed
Google Scholar
Petrocca F, Vecchione A, Croce CM: Emerging role of miR-106b-25/miR-17-92 clusters in the control of transforming growth factor beta signaling. Cancer Res. 2008, 68 (20): 8191-8194. 10.1158/0008-5472.CAN-08-1768.
CAS
PubMed
Google Scholar
Takahashi Y, Forrest AR, Maeno E, Hashimoto T, Daub CO, Yasuda J: MiR-107 and MiR-185 can induce cell cycle arrest in human non small cell lung cancer cell lines. PLoS One. 2009, 4 (8): e6677-10.1371/journal.pone.0006677.
PubMed Central
PubMed
Google Scholar
Song B, Wang Y, Kudo K, Gavin EJ, Xi Y, Ju J: miR-192 Regulates dihydrofolate reductase and cellular proliferation through the p53-microRNA circuit. Clin Cancer Res. 2008, 14 (24): 8080-8086. 10.1158/1078-0432.CCR-08-1422.
PubMed Central
CAS
PubMed
Google Scholar
Chao A, Tsai CL, Wei PC, Hsueh S, Chao AS, Wang CJ, Tsai CN, Lee YS, Wang TH, Lai CH: Decreased expression of microRNA-199b increases protein levels of SET (protein phosphatase 2A inhibitor) in human choriocarcinoma. Cancer Lett. 291 (1): 99-107.
Barroso-delJesus A, Romero-Lopez C, Lucena-Aguilar G, Melen GJ, Sanchez L, Ligero G, Berzal-Herranz A, Menendez P: Embryonic stem cell-specific miR302-367 cluster: human gene structure and functional characterization of its core promoter. Mol Cell Biol. 2008, 28 (21): 6609-6619. 10.1128/MCB.00398-08.
PubMed Central
CAS
PubMed
Google Scholar
Xie X, Lu J, Kulbokas EJ, Golub TR, Mootha V, Lindblad-Toh K, Lander ES, Kellis M: Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals. Nature. 2005, 434 (7031): 338-345. 10.1038/nature03441.
PubMed Central
CAS
PubMed
Google Scholar
Nakano H, Miyazawa T, Kinoshita K, Yamada Y, Yoshida T: Functional screening identifies a microRNA, miR-491 that induces apoptosis by targeting Bcl-X(L) in colorectal cancer cells. Int J Cancer. 2009, 127 (5): 1072-1080. 10.1002/ijc.25143.
Google Scholar
Roshan R, Ghosh T, Scaria V, Pillai B: MicroRNAs: novel therapeutic targets in neurodegenerative diseases. Drug Discov Today. 2009, 14 (23–24): 1123-1129.
CAS
PubMed
Google Scholar
Junn E, Lee KW, Jeong BS, Chan TW, Im JY, Mouradian MM: Repression of alpha-synuclein expression and toxicity by microRNA-7. Proc Natl Acad Sci U S A. 2009, 106 (31): 13052-13057. 10.1073/pnas.0906277106.
PubMed Central
CAS
PubMed
Google Scholar
Zhang W, Wang T, Pei Z, Miller DS, Wu X, Block ML, Wilson B, Zhou Y, Hong JS, Zhang J: Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease. FASEB J. 2005, 19 (6): 533-542. 10.1096/fj.04-2751com.
CAS
PubMed
Google Scholar
Tian T, Wang Y, Wang H, Zhu Z, Xiao Z: Visualizing of the cellular uptake and intracellular trafficking of exosomes by live-cell microscopy. J Cell Biochem. 2010, 111 (2): 488-496. 10.1002/jcb.22733.
CAS
PubMed
Google Scholar
Stoeckl L, Funk A, Kopitzki A, Brandenburg B, Oess S, Will H, Sirma H, Hildt E: Identification of a structural motif crucial for infectivity of hepatitis B viruses. Proc Natl Acad Sci U S A. 2006, 103 (17): 6730-6734. 10.1073/pnas.0509765103.
PubMed Central
CAS
PubMed
Google Scholar
Keller S, Ridinger J, Rupp AK, Janssen JW, Altevogt P: Body fluid derived exosomes as a novel template for clinical diagnostics. Journal of translational medicine. 2011, 9: 86-10.1186/1479-5876-9-86.
PubMed Central
CAS
PubMed
Google Scholar
Papahadjopoulos D, Miller N: Phospholipid model membranes. I. Structural characteristics of hydrated liquid crystals. Biochim Biophys Acta. 1967, 135 (4): 624-638.
CAS
PubMed
Google Scholar
Denzer K, Kleijmeer MJ, Heijnen HF, Stoorvogel W, Geuze HJ: Exosome: from internal vesicle of the multivesicular body to intercellular signaling device. J Cell Sci. 2000, 113 (Pt 19): 3365-3374.
CAS
PubMed
Google Scholar
Johnstone RM: Exosomes biological significance: A concise review. Blood cells, molecules & diseases. 2006, 36 (2): 315-321. 10.1016/j.bcmd.2005.12.001.
CAS
Google Scholar
Mathivanan S, Ji H, Simpson RJ: Exosomes: extracellular organelles important in intercellular communication. Journal of proteomics. 2010, 73 (10): 1907-1920. 10.1016/j.jprot.2010.06.006.
CAS
PubMed
Google Scholar
Fader CM, Sanchez D, Furlan M, Colombo MI: Induction of autophagy promotes fusion of multivesicular bodies with autophagic vacuoles in k562 cells. Traffic. 2008, 9 (2): 230-250.
CAS
PubMed
Google Scholar
Klionsky DJ, Abeliovich H, Agostinis P, Agrawal DK, Aliev G, Askew DS, Baba M, Baehrecke EH, Bahr BA, Ballabio A, et al: Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy. 2008, 4 (2): 151-175.
PubMed Central
CAS
PubMed
Google Scholar
Faure J, Lachenal G, Court M, Hirrlinger J, Chatellard-Causse C, Blot B, Grange J, Schoehn G, Goldberg Y, Boyer V, et al: Exosomes are released by cultured cortical neurones. Mol Cell Neurosci. 2006, 31 (4): 642-648. 10.1016/j.mcn.2005.12.003.
CAS
PubMed
Google Scholar
van Niel G, Porto-Carreiro I, Simoes S, Raposo G: Exosomes: a common pathway for a specialized function. J Biochem. 2006, 140 (1): 13-21. 10.1093/jb/mvj128.
CAS
PubMed
Google Scholar
Vella LJ, Sharples RA, Lawson VA, Masters CL, Cappai R, Hill AF: Packaging of prions into exosomes is associated with a novel pathway of PrP processing. J Pathol. 2007, 211 (5): 582-590. 10.1002/path.2145.
CAS
PubMed
Google Scholar
Rajendran L, Honsho M, Zahn TR, Keller P, Geiger KD, Verkade P, Simons K: Alzheimer's disease beta-amyloid peptides are released in association with exosomes. Proc Natl Acad Sci U S A. 2006, 103 (30): 11172-11177. 10.1073/pnas.0603838103.
PubMed Central
CAS
PubMed
Google Scholar
Ghidoni R, Benussi L, Binetti G: Exosomes: the Trojan horses of neurodegeneration. Med Hypotheses. 2008, 70 (6): 1226-1227. 10.1016/j.mehy.2007.12.003.
CAS
PubMed
Google Scholar
Hasegawa T, Konno M, Baba T, Sugeno N, Kikuchi A, Kobayashi M, Miura E, Tanaka N, Tamai K, Furukawa K, et al: The AAA-ATPase VPS4 regulates extracellular secretion and lysosomal targeting of alpha-synuclein. PLoS One. 2011, 6 (12): e29460-10.1371/journal.pone.0029460.
PubMed Central
CAS
PubMed
Google Scholar
de Gassart A, Geminard C, Fevrier B, Raposo G, Vidal M: Lipid raft-associated protein sorting in exosomes. Blood. 2003, 102 (13): 4336-4344. 10.1182/blood-2003-03-0871.
CAS
PubMed
Google Scholar
Fortin DL, Troyer MD, Nakamura K, Kubo S, Anthony MD, Edwards RH: Lipid rafts mediate the synaptic localization of alpha-synuclein. J Neurosci. 2004, 24 (30): 6715-6723. 10.1523/JNEUROSCI.1594-04.2004.
CAS
PubMed
Google Scholar
Kubo S, Nemani VM, Chalkley RJ, Anthony MD, Hattori N, Mizuno Y, Edwards RH, Fortin DL: A combinatorial code for the interaction of alpha-synuclein with membranes. J Biol Chem. 2005, 280 (36): 31664-31672. 10.1074/jbc.M504894200.
CAS
PubMed
Google Scholar
Pfefferkorn CM, Heinrich F, Sodt AJ, Maltsev AS, Pastor RW, Lee JC: Depth of alpha-Synuclein in a Bilayer Determined by Fluorescence, Neutron Reflectometry, and Computation. Biophys J. 2012, 102 (3): 613-621. 10.1016/j.bpj.2011.12.051.
PubMed Central
CAS
PubMed
Google Scholar
Aguzzi A, Rajendran L: The transcellular spread of cytosolic amyloids, prions, and prionoids. Neuron. 2009, 64 (6): 783-790. 10.1016/j.neuron.2009.12.016.
CAS
PubMed
Google Scholar
Fang Y, Wu N, Gan X, Yan W, Morrell JC, Gould SJ: Higher-order oligomerization targets plasma membrane proteins and HIV gag to exosomes. PLoS Biol. 2007, 5 (6): e158-10.1371/journal.pbio.0050158.
PubMed Central
PubMed
Google Scholar
Perrin RJ, Woods WS, Clayton DF, George JM: Exposure to long chain polyunsaturated fatty acids triggers rapid multimerization of synucleins. J Biol Chem. 2001, 276 (45): 41958-41962. 10.1074/jbc.M105022200.
CAS
PubMed
Google Scholar
Hughes RC: Secretion of the galectin family of mammalian carbohydrate-binding proteins. Biochim Biophys Acta. 1999, 1473 (1): 172-185. 10.1016/S0304-4165(99)00177-4.
CAS
PubMed
Google Scholar
Mehul B, Hughes RC: Plasma membrane targetting, vesicular budding and release of galectin 3 from the cytoplasm of mammalian cells during secretion. J Cell Sci. 1997, 110 (Pt 10): 1169-1178.
CAS
PubMed
Google Scholar
Liu J, Zhang JP, Shi M, Quinn T, Bradner J, Beyer R, Chen S, Zhang J: Rab11a and HSP90 regulate recycling of extracellular alpha-synuclein. J Neurosci. 2009, 29 (5): 1480-1485. 10.1523/JNEUROSCI.6202-08.2009.
PubMed Central
CAS
PubMed
Google Scholar
Fevrier B, Raposo G: Exosomes: endosomal-derived vesicles shipping extracellular messages. Curr Opin Cell Biol. 2004, 16 (4): 415-421. 10.1016/j.ceb.2004.06.003.
CAS
PubMed
Google Scholar
Ratajczak J, Wysoczynski M, Hayek F, Janowska-Wieczorek A, Ratajczak MZ: Membrane-derived microvesicles: important and underappreciated mediators of cell-to-cell communication. Leukemia. 2006, 20 (9): 1487-1495. 10.1038/sj.leu.2404296.
CAS
PubMed
Google Scholar
Keller S, Sanderson MP, Stoeck A, Altevogt P: Exosomes: from biogenesis and secretion to biological function. Immunol Lett. 2006, 107 (2): 102-108. 10.1016/j.imlet.2006.09.005.
CAS
PubMed
Google Scholar
Thery C, Zitvogel L, Amigorena S: Exosomes: composition, biogenesis and function. Nat Rev Immunol. 2002, 2 (8): 569-579.
CAS
PubMed
Google Scholar
Vincent JP, Magee T: Argosomes: membrane fragments on the run. Trends Cell Biol. 2002, 12 (2): 57-60. 10.1016/S0962-8924(01)02227-9.
CAS
PubMed
Google Scholar
Inouye H, Kirschner DA: Alzheimer's beta-amyloid: insights into fibril formation and structure from Congo red binding. Subcell Biochem. 2005, 38: 203-224. 10.1007/0-387-23226-5_10.
CAS
PubMed
Google Scholar
Sanchez I, Mahlke C, Yuan J: Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders. Nature. 2003, 421 (6921): 373-379. 10.1038/nature01301.
CAS
PubMed
Google Scholar
Rubinsztein DC, Gestwicki JE, Murphy LO, Klionsky DJ: Potential therapeutic applications of autophagy. Nat Rev Drug Discov. 2007, 6 (4): 304-312. 10.1038/nrd2272.
CAS
PubMed
Google Scholar
Bandyopadhyay U, Cuervo AM: Chaperone-mediated autophagy in aging and neurodegeneration: lessons from alpha-synuclein. Exp Gerontol. 2007, 42 (1–2): 120-128.
PubMed
Google Scholar
Bennett MC, Bishop JF, Leng Y, Chock PB, Chase TN, Mouradian MM: Degradation of α-synuclein by the proteasome. J Biol Chem. 1999, 274 (48): 33855-33858. 10.1074/jbc.274.48.33855.
CAS
PubMed
Google Scholar
Vogiatzi T, Xilouri M, Vekrellis K, Stefanis L: Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells. J Biol Chem. 2008, 283 (35): 23542-23556. 10.1074/jbc.M801992200.
PubMed Central
CAS
PubMed
Google Scholar
Webb JL, Ravikumar B, Atkins J, Skepper JN, Rubinsztein DC: Alpha-Synuclein is degraded by both autophagy and the proteasome. J Biol Chem. 2003, 278 (27): 25009-25013. 10.1074/jbc.M300227200.
CAS
PubMed
Google Scholar
Yamamoto A, Tagawa Y, Yoshimori T, Moriyama Y, Masaki R, Tashiro Y: Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells. Cell Struct Funct. 1998, 23 (1): 33-42. 10.1247/csf.23.33.
CAS
PubMed
Google Scholar