Articles
Page 19 of 27
-
Citation: Molecular Neurodegeneration 2013 8(Suppl 1):O32
-
Genetic modulation of soluble Aβ rescues cognitive and synaptic impairment in a mouse model of AD
Citation: Molecular Neurodegeneration 2013 8(Suppl 1):O30 -
A novel mechanism underlying pathogenesis of Down syndrome
Citation: Molecular Neurodegeneration 2013 8(Suppl 1):O23 -
O-GlcNAcylation increases non-amyloidogenic processing of the amyloid-β precursor protein (APP)
Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P21 -
Vascular hypothesis of Alzheimer’s disease: role of apoE and apoE receptors
Citation: Molecular Neurodegeneration 2013 8(Suppl 1):O20 -
Regulation of key proteins in Alzheimer’s disease molecular pathogenesis by ubiquilin-1
Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P20 -
Novel non-carbohydrate O-GlcNAcase inhibitors with CNS drug properties as potential treatment for Alzheimer’s disease and tauopathies
Citation: Molecular Neurodegeneration 2013 8(Suppl 1):O17 -
A cell-based model of pathological tau uptake and propagation
Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P17 -
Expanded G4C2 repeats linked to C9ORF72ALS and FTD form length-dependent RNA foci, sequester RNA binding proteins and are neurotoxic
Citation: Molecular Neurodegeneration 2013 8(Suppl 1):O14 -
Function and dysfunction of presenilin in Alzheimer’s disease
Citation: Molecular Neurodegeneration 2013 8(Suppl 1):O11 -
Rapamycin increases survival in ALS mice lacking mature lymphocytes
Amyotrophic Lateral Sclerosis (ALS) is a devastating progressive neurodegenerative disease. Disease pathophysiology is complex and not yet fully understood, but is proposed to include the accumulation of misfo...
Citation: Molecular Neurodegeneration 2013 8:31 -
Amyotrophic lateral sclerosis-linked FUS/TLS alters stress granule assembly and dynamics
Amyotrophic lateral sclerosis (ALS)-linked fused in sarcoma/translocated in liposarcoma (FUS/TLS or FUS) is concentrated within cytoplasmic stress granules under conditions of induced stress. Since only the mu...
Citation: Molecular Neurodegeneration 2013 8:30 -
S-Nitrosylation of parkin as a novel regulator of p53-mediated neuronal cell death in sporadic Parkinson’s disease
Mutations in the gene encoding parkin, a neuroprotective protein with dual functions as an E3 ubiquitin ligase and transcriptional repressor of p53, are linked to familial forms of Parkinson’s disease (PD). We...
Citation: Molecular Neurodegeneration 2013 8:29 -
Genetics of amyotrophic lateral sclerosis: an update
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder involving both upper motor neurons (UMN) and lower motor neurons (LMN). Enormous research has been done in the past few decades i...
Citation: Molecular Neurodegeneration 2013 8:28 -
Autophagy is involved in oligodendroglial precursor-mediated clearance of amyloid peptide
Accumulation of β-amyloid peptides is an important hallmark of Alzheimer’s disease (AD). Tremendous efforts have been directed to elucidate the mechanisms of β-amyloid peptides degradation and develop strategi...
Citation: Molecular Neurodegeneration 2013 8:27 -
Erratum to: treatment with bexarotene, a compound that increases apolipoprotein-E, provides no cognitive benefit in mutant APP/PS1 mice
Citation: Molecular Neurodegeneration 2013 8:26 -
LRP1 is critical for the surface distribution and internalization of the NR2B NMDA receptor subtype
The N-methyl-D-aspartate receptors are key mediators of excitatory transmission and are implicated in many forms of synaptic plasticity. These receptors are heterotetrameres consisting of two obligatory NR1 an...
Citation: Molecular Neurodegeneration 2013 8:25 -
Overcoming barriers and thresholds – signaling of oligomeric Aβ through the prion protein to Fyn
Evidence has been mounting for an involvement of the prion protein (PrP) in a molecular pathway assumed to play a critical role in the etiology of Alzheimer disease. A currently popular model sees oligomeric a...
Citation: Molecular Neurodegeneration 2013 8:24 -
The synaptic maintenance problem: membrane recycling, Ca2+homeostasis and late onset degeneration
Most neurons are born with the potential to live for the entire lifespan of the organism. In addition, neurons are highly polarized cells with often long axons, extensively branched dendritic trees and many sy...
Citation: Molecular Neurodegeneration 2013 8:23 -
Voluntary exercise protects against methamphetamine-induced oxidative stress in brain microvasculature and disruption of the blood–brain barrier
There is no effective therapeutic intervention developed targeting cerebrovascular toxicity of drugs of abuse, including methamphetamine (METH). We hypothesize that exercise protects against METH-induced disru...
Citation: Molecular Neurodegeneration 2013 8:22 -
Progressive morphological changes and impaired retinal function associated with temporal regulation of gene expression after retinal ischemia/reperfusion injury in mice
Retinal ischemia/reperfusion (I/R) injury is an important cause of visual impairment. However, questions remain on the overall I/R mechanisms responsible for progressive damage to the retina. In this study, we...
Citation: Molecular Neurodegeneration 2013 8:21 -
Fluid biomarkers in Alzheimer’s disease – current concepts
The diagnostic guidelines of Alzheimer’s disease (AD) have recently been updated to include brain imaging and cerebrospinal fluid (CSF) biomarkers, with the aim of increasing the certainty of whether a patient...
Citation: Molecular Neurodegeneration 2013 8:20 -
TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson’s disease
A rare variant in the Triggering Receptor Expressed on Myeloid cells 2 (TREM2) gene has been reported to be a genetic risk factor for Alzheimer’s disease by two independent groups (Odds ratio between 2.9-4.5). Gi...
Citation: Molecular Neurodegeneration 2013 8:19 -
Treatment with bexarotene, a compound that increases apolipoprotein-E, provides no cognitive benefit in mutant APP/PS1 mice
Though the precise cause(s) of Alzheimer’s disease (AD) remain unknown, there is strong evidence that decreased clearance of β-amyloid (Aβ) from the brain can contribute to the disease. Therapeutic strategies ...
Citation: Molecular Neurodegeneration 2013 8:18 -
Conformational templating of α-synuclein aggregates in neuronal-glial cultures
Genetic studies have established a causative role for α-synuclein (αS) in Parkinson’s disease (PD), and the presence of αS aggregates in the form of Lewy body (LB) and Lewy neurite (LN) protein inclusions are ...
Citation: Molecular Neurodegeneration 2013 8:17 -
ApoE4 induces Aβ42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice
Recent findings suggest that the pathological effects of apoE4, the most prevalent genetic risk factor for Alzheimer’s disease (AD), start many years before the onset of the disease and are already detectable ...
Citation: Molecular Neurodegeneration 2013 8:16 -
Normal cognition in transgenic BRI2-Aβ mice
Recent research in Alzheimer’s disease (AD) field has been focused on the potential role of the amyloid-β protein that is derived from the transmembrane amyloid precursor protein (APP) in directly mediating co...
Citation: Molecular Neurodegeneration 2013 8:15 -
Behavioral characterization of the 6-hydroxidopamine model of Parkinson’s disease and pharmacological rescuing of non-motor deficits
Parkinson’s disease (PD) is a chronic neurodegenerative condition that is characterized by motor symptoms as a result of dopaminergic degeneration, particularly in the mesostriatal pathway. However, in recent ...
Citation: Molecular Neurodegeneration 2013 8:14 -
In vivo measurement of apolipoprotein E from the brain interstitial fluid using microdialysis
The APOE4 allele variant is the strongest known genetic risk factor for developing late-onset Alzheimer’s disease. The link between apolipoprotein E (apoE) and Alzheimer’s disease is likely due in large part to t...
Citation: Molecular Neurodegeneration 2013 8:13 -
Simultaneous and independent detection of C9ORF72 alleles with low and high number of GGGGCC repeats using an optimised protocol of Southern blot hybridisation
Sizing of GGGGCC hexanucleotide repeat expansions within the C9ORF72 locus, which account for approximately 10% of all amyotrophic lateral sclerosis (ALS) cases, is urgently required to answer fundamental questio...
Citation: Molecular Neurodegeneration 2013 8:12 -
Reviewer acknowledgement
The editors of Molecular Neurodegeneration would like to thank all the reviewers who have contributed to the journal in Volume 7 (2012).
Citation: Molecular Neurodegeneration 2013 8:11 -
Role of p73 in Alzheimer disease: lack of association in mouse models or in human cohorts
P73 belongs to the p53 family of cell survival regulators with the corresponding locus Trp73 producing the N-terminally distinct isoforms, TAp73 and DeltaNp73. Recently, two studies have implicated the murine Trp...
Citation: Molecular Neurodegeneration 2013 8:10 -
In vivo functional brain mapping in a conditional mouse model of human tauopathy (taup301l) reveals reduced neural activity in memory formation structures
Tauopathies are characterized by intracellular deposition of the microtubule-associated protein tau as filamentous aggregates. The rTg4510 mouse conditionally expresses mutant human tau protein in various fore...
Citation: Molecular Neurodegeneration 2013 8:9 -
Age-dependent roles of peroxisomes in the hippocampus of a transgenic mouse model of Alzheimer’s disease
Alzheimer’s Disease (AD) is a progressive neurodegenerative disease, especially affecting the hippocampus. Impairment of cognitive and memory functions is associated with amyloid β-peptide-induced oxidative st...
Citation: Molecular Neurodegeneration 2013 8:8 -
HDAC6 as a target for neurodegenerative diseases: what makes it different from the other HDACs?
Histone deacetylase (HDAC) inhibitors have been demonstrated to be beneficial in animal models of neurodegenerative diseases. Such results were mainly associated with the epigenetic modulation caused by HDACs,...
Citation: Molecular Neurodegeneration 2013 8:7 -
Mitochondrial quality, dynamics and functional capacity in Parkinson’s disease cybrid cell lines selected for Lewy body expression
Lewy bodies (LB) are a neuropathological hallmark of Parkinson’s disease (PD) and other synucleinopathies. The role their formation plays in disease pathogenesis is not well understood, in part because studies...
Citation: Molecular Neurodegeneration 2013 8:6 -
Aggregation and neurotoxicity of recombinant α-synuclein aggregates initiated by dimerization
Aggregation of the α-Synuclein (α-Syn) protein, amyloid fibril formation and progressive neurodegeneration are the neuropathological hallmarks of Parkinson's Disease (PD). However, a detailed mechanism of α-Sy...
Citation: Molecular Neurodegeneration 2013 8:5 -
Kinetics of neurodegeneration based on a risk-related biomarker in animal model of glaucoma
Neurodegenerative diseases including Parkinson’s and Alzheimer’s diseases progress slowly and steadily over years or decades. They show significant between-subject variation in progress and clinical symptoms, ...
Citation: Molecular Neurodegeneration 2013 8:4 -
Aβ impairs nicotinic regulation of inhibitory synaptic transmission and interneuron excitability in prefrontal cortex
Accumulation of β-amyloid (Aβ) and cholinergic deficiency are two prominent features of Alzheimer’s disease (AD). To understand how Aβ-induced dysfunction of the nicotinic system may contribute to cognitive im...
Citation: Molecular Neurodegeneration 2013 8:3 -
Neuron loss in the 5XFAD mouse model of Alzheimer’s disease correlates with intraneuronal Aβ42 accumulation and Caspase-3 activation
Although the mechanism of neuron loss in Alzheimer’s disease (AD) is enigmatic, it is associated with cerebral accumulation of Aβ42. The 5XFAD mouse model of amyloid deposition expresses five familial AD (FAD) mu...
Citation: Molecular Neurodegeneration 2013 8:2 -
Widespread aggregation of mutant VAPB associated with ALS does not cause motor neuron degeneration or modulate mutant SOD1 aggregation and toxicity in mice
A proline-to-serine substitution at position-56 (P56S) of vesicle-associated membrane protein-associated protein B (VAPB) causes a form of dominantly inherited motor neuron disease (MND), including typical and...
Citation: Molecular Neurodegeneration 2013 8:1 -
Modulation of γ-secretase by EVP-0015962 reduces amyloid deposition and behavioral deficits in Tg2576 mice
A hallmark of Alzheimer’s disease is the presence of senile plaques in human brain primarily containing the amyloid peptides Aβ42 and Aβ40. Many drug discovery efforts have focused on decreasing the production of...
Citation: Molecular Neurodegeneration 2012 7:61 -
Caspase-9 mediates synaptic plasticity and memory deficits of Danish dementia knock-in mice: caspase-9 inhibition provides therapeutic protection
Mutations in either Aβ Precursor protein (APP) or genes that regulate APP processing, such as BRI2/ITM2B and PSEN1/PSEN2, cause familial dementias. Although dementias due to APP/PSEN1/PSEN2 mutations are classifi...
Citation: Molecular Neurodegeneration 2012 7:60 -
Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus
Axonal pathology might constitute one of the earliest manifestations of Alzheimer disease. Axonal dystrophies were observed in Alzheimer’s patients and transgenic models at early ages. These axonal dystrophies...
Citation: Molecular Neurodegeneration 2012 7:59 -
The isotropic fractionator provides evidence for differential loss of hippocampal neurons in two mouse models of Alzheimer's disease
The accumulation of amyloid beta (Aβ) oligomers or fibrils is thought to be one of the main causes of synaptic and neuron loss, believed to underlie cognitive dysfunction in Alzheimer’s disease (AD). Neuron lo...
Citation: Molecular Neurodegeneration 2012 7:58 -
Utility of an improved model of amyloid-beta (Aβ1-42) toxicity in Caenorhabditis elegansfor drug screening for Alzheimer’s disease
The definitive indicator of Alzheimer’s disease (AD) pathology is the profuse accumulation of amyloid-ß (Aß) within the brain. Various in vitro and cell-based models have been proposed for high throughput drug sc...
Citation: Molecular Neurodegeneration 2012 7:57 -
Regulated protein aggregation: stress granules and neurodegeneration
The protein aggregation that occurs in neurodegenerative diseases is classically thought to occur as an undesirable, nonfunctional byproduct of protein misfolding. This model contrasts with the biology of RNA ...
Citation: Molecular Neurodegeneration 2012 7:56 -
Involvement of formyl peptide receptors in receptor for advanced glycation end products (RAGE) - and amyloid beta 1-42-induced signal transduction in glial cells
Recent studies suggest that the chemotactic G-protein-coupled-receptor (GPCR) formyl-peptide-receptor-like-1 (FPRL1) and the receptor-for-advanced-glycation-end-products (RAGE) play an important role in the in...
Citation: Molecular Neurodegeneration 2012 7:55 -
Endogenous TDP-43, but not FUS, contributes to stress granule assembly via G3BP
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the selective loss of upper and lower motor neurons, a cell type that is intrinsically more vulnerable than other cell ...
Citation: Molecular Neurodegeneration 2012 7:1 -
Expression of Fused in sarcoma mutations in mice recapitulates the neuropathology of FUS proteinopathies and provides insight into disease pathogenesis
Mutations in the gene encoding the RNA-binding protein fused in sarcoma (FUS) can cause familial and sporadic amyotrophic lateral sclerosis (ALS) and rarely frontotemproal dementia (FTD). FUS accumulates in ne...
Citation: Molecular Neurodegeneration 2012 7:53
Follow
- ISSN: 1750-1326 (electronic)