Articles
Page 6 of 27
-
Citation: Molecular Neurodegeneration 2021 16:74
-
Synaptic dysfunction of Aldh1a1 neurons in the ventral tegmental area causes impulsive behaviors
Aldh1a1 neurons are a subtype of gamma-aminobutyric acid (GABA) inhibitory neurons that use Aldh1a1 rather than glutamate decarboxylase (GAD) as an enzyme for synthesizing GABA transmitters. However, the behav...
Citation: Molecular Neurodegeneration 2021 16:73 -
Correction to: Proteomic landscape of Alzheimer’s Disease: novel insights into pathogenesis and biomarker discovery
Citation: Molecular Neurodegeneration 2021 16:72 -
Impaired antioxidant KEAP1-NRF2 system in amyotrophic lateral sclerosis: NRF2 activation as a potential therapeutic strategy
Oxidative stress (OS) is an imbalance between oxidant and antioxidant species and, together with other numerous pathological mechanisms, leads to the degeneration and death of motor neurons (MNs) in amyotrophi...
Citation: Molecular Neurodegeneration 2021 16:71 -
METTL3-dependent RNA m6A dysregulation contributes to neurodegeneration in Alzheimer’s disease through aberrant cell cycle events
N6-methyladenosine (m6A) modification of RNA influences fundamental aspects of RNA metabolism and m6A dysregulation is implicated in various human diseases. In this study, we explored the potential role of RNA m6
Citation: Molecular Neurodegeneration 2021 16:70 -
The TGFβ/Notch axis facilitates Müller cell-to-epithelial transition to ultimately form a chronic glial scar
Contrasting with zebrafish, retinal regeneration from Müller cells (MCs) is largely limited in mammals, where they undergo reactive gliosis that consist of a hypertrophic response and ultimately results in vis...
Citation: Molecular Neurodegeneration 2021 16:69 -
Human iPSC-derived astrocytes transplanted into the mouse brain undergo morphological changes in response to amyloid-β plaques
Increasing evidence for a direct contribution of astrocytes to neuroinflammatory and neurodegenerative processes causing Alzheimer’s disease comes from molecular and functional studies in rodent models. Howeve...
Citation: Molecular Neurodegeneration 2021 16:68 -
Measuring the cognitive costs of the COVID-19 pandemic
Citation: Molecular Neurodegeneration 2021 16:67 -
Nuclear speckle specific hnRNP D-like prevents age- and AD-related cognitive decline by modulating RNA splicing
Aberrant alternative splicing plays critical role in aging and age-related diseases. Heterogeneous nuclear ribonucleoproteins (hnRNPs) reportedly regulate RNA splicing process. Whether and how hnRNPs contribut...
Citation: Molecular Neurodegeneration 2021 16:66 -
Nuclear dynamics and stress responses in Alzheimer’s disease
In response to extracellular and intracellular stressors, the nucleus and nuclear compartments undergo distinct molecular changes to maintain cell homeostasis. In the context of Alzheimer’s disease, misfolded ...
Citation: Molecular Neurodegeneration 2021 16:65 -
Adult-onset CNS myelin sulfatide deficiency is sufficient to cause Alzheimer’s disease-like neuroinflammation and cognitive impairment
Human genetic association studies point to immune response and lipid metabolism, in addition to amyloid-beta (Aβ) and tau, as major pathways in Alzheimer’s disease (AD) etiology. Accumulating evidence suggests...
Citation: Molecular Neurodegeneration 2021 16:64 -
Collusion of α-Synuclein and Aβ aggravating co-morbidities in a novel prion-type mouse model
The misfolding of host-encoded proteins into pathological prion conformations is a defining characteristic of many neurodegenerative disorders, including Alzheimer’s disease, Parkinson’s disease, and Lewy body...
Citation: Molecular Neurodegeneration 2021 16:63 -
APOΕ4 lowers energy expenditure in females and impairs glucose oxidation by increasing flux through aerobic glycolysis
Cerebral glucose hypometabolism is consistently observed in individuals with Alzheimer’s disease (AD), as well as in young cognitively normal carriers of the Ε4 allele of Apolipoprotein E (APOE), the strongest...
Citation: Molecular Neurodegeneration 2021 16:62 -
Wild-type FUS corrects ALS-like disease induced by cytoplasmic mutant FUS through autoregulation
Mutations in FUS, an RNA-binding protein involved in multiple steps of RNA metabolism, are associated with the most severe forms of amyotrophic lateral sclerosis (ALS). Accumulation of cytoplasmic FUS is likel...
Citation: Molecular Neurodegeneration 2021 16:61 -
Functional microRNA targetome undergoes degeneration-induced shift in the retina
MicroRNA (miRNA) play a significant role in the pathogenesis of complex neurodegenerative diseases including age-related macular degeneration (AMD), acting as post-transcriptional gene suppressors through thei...
Citation: Molecular Neurodegeneration 2021 16:60 -
Extracellular protein components of amyloid plaques and their roles in Alzheimer’s disease pathology
Alzheimer’s disease (AD) is pathologically defined by the presence of fibrillar amyloid β (Aβ) peptide in extracellular senile plaques and tau filaments in intracellular neurofibrillary tangles. Extensive rese...
Citation: Molecular Neurodegeneration 2021 16:59 -
Sex dependent glial-specific changes in the chromatin accessibility landscape in late-onset Alzheimer’s disease brains
In the post-GWAS era, there is an unmet need to decode the underpinning genetic etiologies of late-onset Alzheimer’s disease (LOAD) and translate the associations to causation.
Citation: Molecular Neurodegeneration 2021 16:58 -
Cellular and pathological heterogeneity of primary tauopathies
Microtubule-associated protein tau is abnormally aggregated in neuronal and glial cells in a range of neurodegenerative diseases that are collectively referred to as tauopathies. Multiple studies have suggeste...
Citation: Molecular Neurodegeneration 2021 16:57 -
Vesicle trafficking and pathways to neurodegeneration
Citation: Molecular Neurodegeneration 2021 16:56 -
Proteomic landscape of Alzheimer’s Disease: novel insights into pathogenesis and biomarker discovery
Mass spectrometry-based proteomics empowers deep profiling of proteome and protein posttranslational modifications (PTMs) in Alzheimer’s disease (AD). Here we review the advances and limitations in historic an...
Citation: Molecular Neurodegeneration 2021 16:55 -
Microglial inclusions and neurofilament light chain release follow neuronal α-synuclein lesions in long-term brain slice cultures
Proteopathic brain lesions are a hallmark of many age-related neurodegenerative diseases including synucleinopathies and develop at least a decade before the onset of clinical symptoms. Thus, understanding of ...
Citation: Molecular Neurodegeneration 2021 16:54 -
SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis
Loss of motor neurons in amyotrophic lateral sclerosis (ALS) leads to progressive paralysis and death. Dysregulation of thousands of RNA molecules with roles in multiple cellular pathways hinders the identific...
Citation: Molecular Neurodegeneration 2021 16:53 -
Decoding distinctive features of plasma extracellular vesicles in amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a multifactorial, multisystem motor neuron disease for which currently there is no effective treatment. There is an urgent need to identify biomarkers to tackle the disea...
Citation: Molecular Neurodegeneration 2021 16:52 -
Processing of progranulin into granulins involves multiple lysosomal proteases and is affected in frontotemporal lobar degeneration
Progranulin loss-of-function mutations are linked to frontotemporal lobar degeneration with TDP-43 positive inclusions (FTLD-TDP-Pgrn). Progranulin (PGRN) is an intracellular and secreted pro-protein that is prot...
Citation: Molecular Neurodegeneration 2021 16:51 -
Plaque-associated human microglia accumulate lipid droplets in a chimeric model of Alzheimer’s disease
Disease-associated microglia (DAMs), that surround beta-amyloid plaques, represent a transcriptionally-distinct microglial profile in Alzheimer’s disease (AD). Activation of DAMs is dependent on triggering rec...
Citation: Molecular Neurodegeneration 2021 16:50 -
The informed road map to prevention of Alzheimer Disease: A call to arms
Alzheimer disease (AD) prevention trials hold the promise to delay or prevent cognitive decline and dementia onset by intervening before significant neuronal damage occurs. In recent years, the first AD preven...
Citation: Molecular Neurodegeneration 2021 16:49 -
Post-infection cognitive impairments in a cohort of elderly patients with COVID-19
Understanding the long-term effects of coronavirus disease 2019 (COVID-19) on cognitive function is essential for monitoring the cognitive decline in the elderly population. This study aims to assess the curre...
Citation: Molecular Neurodegeneration 2021 16:48 -
Knock-in models related to Alzheimer’s disease: synaptic transmission, plaques and the role of microglia
Microglia are active modulators of Alzheimer’s disease but their role in relation to amyloid plaques and synaptic changes due to rising amyloid beta is unclear. We add novel findings concerning these relations...
Citation: Molecular Neurodegeneration 2021 16:47 -
SETD7-mediated monomethylation is enriched on soluble Tau in Alzheimer’s disease
Human tauopathies including Alzheimer’s disease (AD) are characterized by alterations in the post-translational modification (PTM) pattern of Tau, which parallel the formation of insoluble Tau aggregates, neur...
Citation: Molecular Neurodegeneration 2021 16:46 -
Accumulation of saposin in dystrophic neurites is linked to impaired lysosomal functions in Alzheimer’s disease brains
Neuritic plaques in Alzheimer’s disease (AD) brains refer to β-amyloid (Aβ) plaques surrounded by dystrophic neurites (DNs), activated microglia and reactive astrocytes. Most recently, we showed that DNs form ...
Citation: Molecular Neurodegeneration 2021 16:45 -
Mammalian/mechanistic target of rapamycin (mTOR) complexes in neurodegeneration
Novel targets to arrest neurodegeneration in several dementing conditions involving misfolded protein accumulations may be found in the diverse signaling pathways of the Mammalian/mechanistic target of rapamyc...
Citation: Molecular Neurodegeneration 2021 16:44 -
AMPK hyperactivation promotes dendrite retraction, synaptic loss, and neuronal dysfunction in glaucoma
The maintenance of complex dendritic arbors and synaptic transmission are processes that require a substantial amount of energy. Bioenergetic decline is a prominent feature of chronic neurodegenerative disease...
Citation: Molecular Neurodegeneration 2021 16:43 -
Correction to: A pharmacological chaperone improves memory by reducing Aβ and tau neuropathology in a mouse model with plaques and tangles
Citation: Molecular Neurodegeneration 2021 16:42 -
Pharmacological rescue of cognitive function in a mouse model of chemobrain
After chemotherapy, many cancer survivors suffer from long-lasting cognitive impairment, colloquially known as “chemobrain.” However, the trajectories of cognitive changes and the underlying mechanisms remain ...
Citation: Molecular Neurodegeneration 2021 16:41 -
A proteomic network approach resolves stage-specific molecular phenotypes in chronic traumatic encephalopathy
There is an association between repetitive head injury (RHI) and a pathologic diagnosis of chronic traumatic encephalopathy (CTE) characterized by the aggregation of proteins including tau. The underlying mole...
Citation: Molecular Neurodegeneration 2021 16:40 -
Key role of the CCR2-CCL2 axis in disease modification in a mouse model of tauopathy
For decades, dementia has been characterized by accumulation of waste in the brain and low-grade inflammation. Over the years, emerging studies highlighted the involvement of the immune system in neurodegenera...
Citation: Molecular Neurodegeneration 2021 16:39 -
Identification of sixteen novel candidate genes for late onset Parkinson’s disease
Parkinson’s disease (PD) is a neurodegenerative movement disorder affecting 1–5% of the general population for which neither effective cure nor early diagnostic tools are available that could tackle the pathol...
Citation: Molecular Neurodegeneration 2021 16:35 -
Brain mechanisms underlying neuropsychiatric symptoms in Alzheimer’s disease: a systematic review of symptom-general and –specific lesion patterns
Neuropsychiatric symptoms (NPSs) are common in patients with Alzheimer’s disease (AD) and are associated with accelerated cognitive impairment and earlier deaths. This review aims to explore the neural pathoge...
Citation: Molecular Neurodegeneration 2021 16:38 -
“Don’t Phos Over Tau”: recent developments in clinical biomarkers and therapies targeting tau phosphorylation in Alzheimer’s disease and other tauopathies
Phosphorylation is one of the most prevalent post-translational modifications found in aggregated tau isolated from Alzheimer’s disease (AD) patient brains. In tauopathies like AD, increased phosphorylation or...
Citation: Molecular Neurodegeneration 2021 16:37 -
Neuroprotection by WldS depends on retinal ganglion cell type and age in glaucoma
Early challenges to axonal physiology, active transport, and ultrastructure are endemic to age-related neurodegenerative disorders, including those affecting the optic nerve. Chief among these, glaucoma causes...
Citation: Molecular Neurodegeneration 2021 16:36 -
Parkinson mice show functional and molecular changes in the gut long before motoric disease onset
There is increasing evidence that Parkinson’s disease (PD) might start in the gut, thus involving and compromising also the enteric nervous system (ENS). At the clinical onset of the disease the majority of do...
Citation: Molecular Neurodegeneration 2021 16:34 -
Oligomerization of Lrrk controls actin severing and α-synuclein neurotoxicity in vivo
Mutations in LRRK2 are the most common cause of familial Parkinson’s disease and typically cause disease in the context of abnormal aggregation and deposition of α-synuclein within affected brain tissue.
Citation: Molecular Neurodegeneration 2021 16:33 -
Modulating innate immune activation states impacts the efficacy of specific Aβ immunotherapy
Passive immunotherapies targeting Aβ continue to be evaluated as Alzheimer’s disease (AD) therapeutics, but there remains debate over the mechanisms by which these immunotherapies work. Besides the amount of p...
Citation: Molecular Neurodegeneration 2021 16:32 -
Genome-wide histone acetylation analysis reveals altered transcriptional regulation in the Parkinson’s disease brain
Parkinson’s disease (PD) is a complex, age-related neurodegenerative disorder of largely unknown etiology. PD is strongly associated with mitochondrial respiratory dysfunction, which can lead to epigenetic dys...
Citation: Molecular Neurodegeneration 2021 16:31 -
A blood-based diagnostic test incorporating plasma Aβ42/40 ratio, ApoE proteotype, and age accurately identifies brain amyloid status: findings from a multi cohort validity analysis
The development of blood-based biomarker tests that are accurate and robust for Alzheimer’s disease (AD) pathology have the potential to aid clinical diagnosis and facilitate enrollment in AD drug trials. We d...
Citation: Molecular Neurodegeneration 2021 16:30 -
Protective genes and pathways in Alzheimer’s disease: moving towards precision interventions
Alzheimer’s disease (AD) is a progressive, neurodegenerative disorder that is characterized by neurodegeneration, cognitive impairment, and an eventual inability to perform daily tasks. The etiology of Alzheim...
Citation: Molecular Neurodegeneration 2021 16:29 -
Mitochondrial complex I abnormalities is associated with tau and clinical symptoms in mild Alzheimer’s disease
Mitochondrial electron transport chain abnormalities have been reported in postmortem pathological specimens of Alzheimer’s disease (AD). However, it remains unclear how amyloid and tau are associated with mit...
Citation: Molecular Neurodegeneration 2021 16:28 -
Beyond association: successes and challenges in linking non-coding genetic variation to functional consequences that modulate Alzheimer’s disease risk
Alzheimer’s disease (AD) is the most common type of dementia, affecting millions of people worldwide; however, no disease-modifying treatments are currently available. Genome-wide association studies (GWASs) h...
Citation: Molecular Neurodegeneration 2021 16:27 -
RETRACTED ARTICLE: Calcium-dependent cytosolic phospholipase A2 activation is implicated in neuroinflammation and oxidative stress associated with ApoE4
Apolipoprotein E4 (APOE4) is associated with a greater response to neuroinflammation and the risk of developing late-onset Alzheimer’s disease (AD), but the mechanisms for this association are not clear. The acti...
Citation: Molecular Neurodegeneration 2021 16:26 -
Correction to: Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model
An amendment to this paper has been published and can be accessed via the original article.
Citation: Molecular Neurodegeneration 2021 16:24
Follow
- ISSN: 1750-1326 (electronic)