Rector RS, Thyfault JP, Wei Y, Ibdah JA: Non-alcoholic fatty liver disease and the metabolic syndrome: an update. World J Gastroenterol. 2008, 14 (2): 185-192. 10.3748/wjg.14.185.
PubMed Central
CAS
PubMed
Google Scholar
Pradhan A: Obesity, metabolic syndrome, and type 2 diabetes: inflammatory basis of glucose metabolic disorders. Nutr Rev. 2007, 65 (12 Pt 2): S152-156. 10.1111/j.1753-4887.2007.tb00354.x.
PubMed
Google Scholar
Launer LJ: Next steps in Alzheimer's disease research: interaction between epidemiology and basic science. Curr Alzheimer Res. 2007, 4 (2): 141-143. 10.2174/156720507780362155.
CAS
PubMed
Google Scholar
Wang G, Silva J, Dasgupta S, Bieberich E: Long-chain ceramide is elevated in presenilin 1 (PS1M146V) mouse brain and induces apoptosis in PS1 astrocytes. Glia. 2008, 56 (4): 449-456. 10.1002/glia.20626.
PubMed
Google Scholar
Delgado JS: Evolving trends in nonalcoholic fatty liver disease. Eur J Intern Med. 2008, 19 (2): 75-82. 10.1016/j.ejim.2007.02.034.
CAS
PubMed
Google Scholar
Nugent C, Younossi ZM: Evaluation and management of obesity-related nonalcoholic fatty liver disease. Nat Clin Pract Gastroenterol Hepatol. 2007, 4 (8): 432-441. 10.1038/ncpgasthep0879.
PubMed
Google Scholar
de la Monte SM, Neusner A, Chu J, Lawton M: Epidemilogical Trends Strongly Suggest Exposures as Etiologic Agents in the Pathogenesis of Sporadic Alzheimer's Disease, Diabetes Mellitus, and Non-Alcoholic Steatohepatitis. J Alzheimers Dis. 2009, 17 (3): 519-529.
PubMed Central
CAS
PubMed
Google Scholar
Swann PF, Magee PN: Nitrosamine-induced carcinogenesis. The alklylation of nucleic acids of the rat by N-methyl-N-nitrosourea, dimethylnitrosamine, dimethyl sulphate and methyl methanesulphonate. Biochem J. 1968, 110 (1): 39-47.
PubMed Central
CAS
PubMed
Google Scholar
Espey MG, Miranda KM, Thomas DD, Xavier S, Citrin D, Vitek MP, Wink DA: A chemical perspective on the interplay between NO, reactive oxygen species, and reactive nitrogen oxide species. Ann N Y Acad Sci. 2002, 962: 195-206. 10.1111/j.1749-6632.2002.tb04068.x.
CAS
PubMed
Google Scholar
Pasquier F, Boulogne A, Leys D, Fontaine P: Diabetes mellitus and dementia. Diabetes Metab. 2006, 32 (5 Pt 1): 403-414. 10.1016/S1262-3636(07)70298-7.
CAS
PubMed
Google Scholar
Nicolls MR: The clinical and biological relationship between Type II diabetes mellitus and Alzheimer's disease. Curr Alzheimer Res. 2004, 1 (1): 47-54. 10.2174/1567205043480555.
CAS
PubMed
Google Scholar
Yeh MM, Brunt EM: Pathology of nonalcoholic fatty liver disease. Am J Clin Pathol. 2007, 128 (5): 837-847. 10.1309/RTPM1PY6YGBL2G2R.
PubMed
Google Scholar
Marchesini G, Marzocchi R: Metabolic syndrome and NASH. Clin Liver Dis. 2007, 11 (1): 105-117. 10.1016/j.cld.2007.02.013. ix
PubMed
Google Scholar
Papandreou D, Rousso I, Mavromichalis I: Update on non-alcoholic fatty liver disease in children. Clin Nutr. 2007, 26 (4): 409-415. 10.1016/j.clnu.2007.02.002.
CAS
PubMed
Google Scholar
Pessayre D: Role of mitochondria in non-alcoholic fatty liver disease. J Gastroenterol Hepatol. 2007, 22 (Suppl 1): S20-27. 10.1111/j.1440-1746.2006.04640.x.
CAS
PubMed
Google Scholar
Wei Y, Rector RS, Thyfault JP, Ibdah JA: Nonalcoholic fatty liver disease and mitochondrial dysfunction. World J Gastroenterol. 2008, 14 (2): 193-199. 10.3748/wjg.14.193.
PubMed Central
CAS
PubMed
Google Scholar
Bolzan AD, Bianchi MS: Genotoxicity of streptozotocin. Mutat Res. 2002, 512 (2-3): 121-134. 10.1016/S1383-5742(02)00044-3.
CAS
PubMed
Google Scholar
Rossini AA, Like AA, Chick WL, Appel MC, Cahill GF: Studies of streptozotocin-induced insulitis and diabetes. Proc Natl Acad Sci USA. 1977, 74 (6): 2485-2489. 10.1073/pnas.74.6.2485.
PubMed Central
CAS
PubMed
Google Scholar
Szkudelski T: The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. Physiol Res. 2001, 50 (6): 537-546.
CAS
PubMed
Google Scholar
Doi K: [Studies on the mechanism of the diabetogenic activity of streptozotocin and on the ability of compounds to block the diabetogenic activity of streptozotocin (author's transl)]. Nippon Naibunpi Gakkai Zasshi. 1975, 51 (3): 129-147.
CAS
PubMed
Google Scholar
Iwai S, Murai T, Makino S, Min W, Morimura K, Mori S, Hagihara A, Seki S, Fukushima S: High sensitivity of fatty liver Shionogi (FLS) mice to diethylnitrosamine hepatocarcinogenesis: comparison to C3H and C57 mice. Cancer Lett. 2007, 246 (1-2): 115-121. 10.1016/j.canlet.2006.02.008.
CAS
PubMed
Google Scholar
de la Monte SM, Tong M, Lester-Coll N, Plater M, Wands JR: Therapeutic rescue of neurodegeneration in experimental type 3 diabetes: relevance to Alzheimer's disease. J Alzheimers Dis. 2006, 10 (1): 89-109.
CAS
PubMed
Google Scholar
Hoyer S: Causes and consequences of disturbances of cerebral glucose metabolism in sporadic Alzheimer disease: therapeutic implications. Adv Exp Med Biol. 2004, 541: 135-152.
CAS
PubMed
Google Scholar
Hoyer S, Lannert H, Noldner M, Chatterjee SS: Damaged neuronal energy metabolism and behavior are improved by Ginkgo biloba extract (EGb 761). J Neural Transm. 1999, 106 (11-12): 1171-1188. 10.1007/s007020050232.
CAS
PubMed
Google Scholar
Lester-Coll N, Rivera EJ, Soscia SJ, Doiron K, Wands JR, de la Monte SM: Intracerebral streptozotocin model of type 3 diabetes: relevance to sporadic Alzheimer's disease. J Alzheimers Dis. 2006, 9 (1): 13-33.
CAS
PubMed
Google Scholar
Murata M, Takahashi A, Saito I, Kawanishi S: Site-specific DNA methylation and apoptosis: induction by diabetogenic streptozotocin. Biochem Pharmacol. 1999, 57 (8): 881-887. 10.1016/S0006-2952(98)00370-0.
CAS
PubMed
Google Scholar
Nukatsuka M, Sakurai H, Yoshimura Y, Nishida M, Kawada J: Enhancement by streptozotocin of O2- radical generation by the xanthine oxidase system of pancreatic beta-cells. FEBS Lett. 1988, 239 (2): 295-298. 10.1016/0014-5793(88)80938-4.
CAS
PubMed
Google Scholar
West IC: Radicals and oxidative stress in diabetes. Diabet Med. 2000, 17 (3): 171-180. 10.1046/j.1464-5491.2000.00259.x.
CAS
PubMed
Google Scholar
Robbiano L, Mereto E, Corbu C, Brambilla G: DNA damage induced by seven N-nitroso compounds in primary cultures of human and rat kidney cells. Mutat Res. 1996, 368 (1): 41-47. 10.1016/S0165-1218(96)90038-5.
CAS
PubMed
Google Scholar
Verdelho A, Madureira S, Ferro JM, Basile AM, Chabriat H, Erkinjuntti T, Fazekas F, Hennerici M, O'Brien J, Pantoni L, Salvadori E, Scheltens P, Visser MC, Wahlund LO, Waldemar G, Wallin A, Inzitari D: Differential impact of cerebral white matter changes, diabetes, hypertension and stroke on cognitive performance among non-disabled elderly. The LADIS study. J Neurol Neurosurg Psychiatry. 2007, 78 (12): 1325-1330. 10.1136/jnnp.2006.110361.
PubMed Central
PubMed
Google Scholar
Martins IJ, Hone E, Foster JK, Sunram-Lea SI, Gnjec A, Fuller SJ, Nolan D, Gandy SE, Martins RN: Apolipoprotein E, cholesterol metabolism, diabetes, and the convergence of risk factors for Alzheimer's disease and cardiovascular disease. Mol Psychiatry. 2006, 11 (8): 721-736. 10.1038/sj.mp.4001854.
CAS
PubMed
Google Scholar
Craft S: Insulin resistance syndrome and Alzheimer disease: pathophysiologic mechanisms and therapeutic implications. Alzheimer Dis Assoc Disord. 2006, 20 (4): 298-301. 10.1097/01.wad.0000213866.86934.7e.
CAS
PubMed
Google Scholar
Craft S: Insulin resistance and Alzheimer's disease pathogenesis: potential mechanisms and implications for treatment. Curr Alzheimer Res. 2007, 4 (2): 147-152. 10.2174/156720507780362137.
CAS
PubMed
Google Scholar
Rivera EJ, Goldin A, Fulmer N, Tavares R, Wands JR, de la Monte SM: Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer's disease: link to brain reductions in acetylcholine. J Alzheimers Dis. 2005, 8 (3): 247-268.
CAS
PubMed
Google Scholar
Steen E, Terry BM, Rivera EJ, Cannon JL, Neely TR, Tavares R, Xu XJ, Wands JR, de la Monte SM: Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease--is this type 3 diabetes?. J Alzheimers Dis. 2005, 7 (1): 63-80.
CAS
PubMed
Google Scholar
Winocur G, Greenwood CE: Studies of the effects of high fat diets on cognitive function in a rat model. Neurobiol Aging. 2005, 26 (Suppl 1): 46-49. 10.1016/j.neurobiolaging.2005.09.003.
PubMed
Google Scholar
Winocur G, Greenwood CE, Piroli GG, Grillo CA, Reznikov LR, Reagan LP, McEwen BS: Memory impairment in obese Zucker rats: an investigation of cognitive function in an animal model of insulin resistance and obesity. Behav Neurosci. 2005, 119 (5): 1389-1395. 10.1037/0735-7044.119.5.1389.
CAS
PubMed
Google Scholar
Lyn-Cook LE, Lawton M, Tong M, Silbermann E, Longato L, Jiao P, Mark P, Wands JR, Xu H, de la Monte SM: Hepatic Ceramide May Mediate Brain Insulin Resistance and Neurodegeneration in Type 2 Diabetes and Non-alcoholic Steatohepatitis. J Alzheimers Dis. 2009, 16 (4): 715-729.
PubMed Central
PubMed
Google Scholar
Moroz N, Tong M, Longato L, Xu H, de la Monte SM: Limited Alzheimer-type neurodegeneration in experimental obesity and type 2 diabetes mellitus. J Alzheimers Dis. 2008, 15 (1): 29-44.
CAS
PubMed
Google Scholar
Biju MP, Paulose CS: Brain glutamate dehydrogenase changes in streptozotocin diabetic rats as a function of age. Biochem Mol Biol Int. 1998, 44 (1): 1-7.
CAS
PubMed
Google Scholar
Nitta A, Murai R, Suzuki N, Ito H, Nomoto H, Katoh G, Furukawa Y, Furukawa S: Diabetic neuropathies in brain are induced by deficiency of BDNF. Neurotoxicol Teratol. 2002, 24 (5): 695-701. 10.1016/S0892-0362(02)00220-9.
CAS
PubMed
Google Scholar
Weinstock M, Shoham S: Rat models of dementia based on reductions in regional glucose metabolism, cerebral blood flow and cytochrome oxidase activity. J Neural Transm. 2004, 111 (3): 347-366. 10.1007/s00702-003-0058-y.
CAS
PubMed
Google Scholar
Haan MN: Therapy Insight: type 2 diabetes mellitus and the risk of late-onset Alzheimer's disease. Nat Clin Pract Neurol. 2006, 2 (3): 159-166. 10.1038/ncpneuro0124.
CAS
PubMed
Google Scholar
Landreth G: Therapeutic use of agonists of the nuclear receptor PPARgamma in Alzheimer's disease. Curr Alzheimer Res. 2007, 4 (2): 159-164. 10.2174/156720507780362092.
CAS
PubMed
Google Scholar
Pedersen WA, McMillan PJ, Kulstad JJ, Leverenz JB, Craft S, Haynatzki GR: Rosiglitazone attenuates learning and memory deficits in Tg2576 Alzheimer mice. Exp Neurol. 2006, 199 (2): 265-273. 10.1016/j.expneurol.2006.01.018.
CAS
PubMed
Google Scholar
Reger MA, Craft S: Intranasal insulin administration: a method for dissociating central and peripheral effects of insulin. Drugs Today (Barc). 2006, 42 (11): 729-739. 10.1358/dot.2006.42.11.1007675.
CAS
Google Scholar
Reger MA, Watson GS, Frey WH, Baker LD, Cholerton B, Keeling ML, Belongia DA, Fishel MA, Plymate SR, Schellenberg GD, Cherrier MM, Craft S: Effects of intranasal insulin on cognition in memory-impaired older adults: modulation by APOE genotype. Neurobiol Aging. 2006, 27 (3): 451-458. 10.1016/j.neurobiolaging.2005.03.016.
CAS
PubMed
Google Scholar
Reger MA, Watson GS, Green PS, Wilkinson CW, Baker LD, Cholerton B, Fishel MA, Plymate SR, Breitner JC, Degroodt W, Mehta P, Craft S: Intranasal insulin improves cognition and modulates {beta}-amyloid in early AD. Neurology. 2008, 70 (6): 440-448. 10.1212/01.WNL.0000265401.62434.36.
CAS
PubMed
Google Scholar
Watson GS, Bernhardt T, Reger MA, Cholerton BA, Baker LD, Peskind ER, Asthana S, Plymate SR, Frolich L, Craft S: Insulin effects on CSF norepinephrine and cognition in Alzheimer's disease. Neurobiol Aging. 2006, 27 (1): 38-41. 10.1016/j.neurobiolaging.2004.11.011.
CAS
PubMed
Google Scholar
Penberthy WT: Pharmacological targeting of IDO-mediated tolerance for treating autoimmune disease. Curr Drug Metab. 2007, 8 (3): 245-266. 10.2174/138920007780362545.
CAS
PubMed
Google Scholar
de la Monte SM, Wands JR: Alzheimer's Disease is Type 3 Diabetes: Evidence Reviewed. J Diabetes Science Tech. 2008, 2 (6): 1101-1113.
Google Scholar
Butler SM, Ashford JW, Snowdon DA: Age, education, and changes in the Mini-Mental State Exam scores of older women: findings from the Nun Study. J Am Geriatr Soc. 1996, 44 (6): 675-681.
CAS
PubMed
Google Scholar
Snowdon DA, Kemper SJ, Mortimer JA, Greiner LH, Wekstein DR, Markesbery WR: Linguistic ability in early life and cognitive function and Alzheimer's disease in late life. Findings from the Nun Study. JAMA. 1996, 275 (7): 528-532. 10.1001/jama.275.7.528.
CAS
PubMed
Google Scholar
de la Monte SM, Wands JR: Review of insulin and insulin-like growth factor expression, signaling, and malfunction in the central nervous system: relevance to Alzheimer's disease. J Alzheimers Dis. 2005, 7 (1): 45-61.
CAS
PubMed
Google Scholar
Hickey RW, Akino M, Strausbaugh S, De Courten-Myers GM: Use of the Morris water maze and acoustic startle chamber to evaluate neurologic injury after asphyxial arrest in rats. Pediatr Res. 1996, 39 (1): 77-84. 10.1203/00006450-199601000-00011.
CAS
PubMed
Google Scholar
Fowler SD, Greenspan P: Application of Nile red, a fluorescent hydrophobic probe, for the detection of neutral lipid deposits in tissue sections: comparison with oil red O. J Histochem Cytochem. 1985, 33 (8): 833-836.
CAS
PubMed
Google Scholar
Greenspan P, Fowler SD: Spectrofluorometric studies of the lipid probe, nile red. J Lipid Res. 1985, 26 (7): 781-789.
CAS
PubMed
Google Scholar
McMillian MK, Grant ER, Zhong Z, Parker JB, Li L, Zivin RA, Burczynski ME, Johnson MD: Nile Red binding to HepG2 cells: an improved assay for in vitro studies of hepatosteatosis. In Vitr Mol Toxicol. 2001, 14 (3): 177-190. 10.1089/109793301753407948.
CAS
PubMed
Google Scholar
Tong M, Neusner A, Longato L, Lawton M, Wands JR, de la Monte SM: Nitrosamine exposure causes insulin resistance diseases: Relevance to type 2 diabetes mellitus, non-alcoholic steatohepatitis, and Alzheimer's disease in humans. J Alz Dis. 2009,
Google Scholar
Cohen AC, Tong M, Wands JR, de la Monte SM: Insulin and insulin-like growth factor resistance with neurodegeneration in an adult chronic ethanol exposure model. Alcohol Clin Exp Res. 2007, 31 (9): 1558-1573. 10.1111/j.1530-0277.2007.00450.x.
CAS
PubMed
Google Scholar
Soscia SJ, Tong M, Xu XJ, Cohen AC, Chu J, Wands JR, de la Monte SM: Chronic gestational exposure to ethanol causes insulin and IGF resistance and impairs acetylcholine homeostasis in the brain. Cell Mol Life Sci. 2006, 63 (17): 2039-2056. 10.1007/s00018-006-6208-2.
CAS
PubMed
Google Scholar
Hietanen E, Bartsch H, Ahotupa M, Bereziat JC, Bussacchini-Griot V, Cabral JR, Camus AM, Laitinen M, Wild H: Mechanisms of fat-related modulation of N-nitrosodiethylamine-induced tumors in rats: organ distribution, blood lipids, enzymes and pro-oxidant state. Carcinogenesis. 1991, 12 (4): 591-600. 10.1093/carcin/12.4.591.
CAS
PubMed
Google Scholar
Cong WN, Tao RY, Tian JY, Liu GT, Ye F: The establishment of a novel non-alcoholic steatohepatitis model accompanied with obesity and insulin resistance in mice. Life Sci. 2008, 82 (19-20): 983-990. 10.1016/j.lfs.2008.01.022.
CAS
PubMed
Google Scholar
Kirsch R, Clarkson V, Verdonk RC, Marais AD, Shephard EG, Ryffel B, de la MHP: Rodent nutritional model of steatohepatitis: effects of endotoxin (lipopolysaccharide) and tumor necrosis factor alpha deficiency. J Gastroenterol Hepatol. 2006, 21 (1 Pt 1): 174-182. 10.1111/j.1440-1746.2005.04220.x.
CAS
PubMed
Google Scholar
Yoshimatsu M, Terasaki Y, Sakashita N, Kiyota E, Sato H, Laan van der LJ, Takeya M: Induction of macrophage scavenger receptor MARCO in nonalcoholic steatohepatitis indicates possible involvement of endotoxin in its pathogenic process. Int J Exp Pathol. 2004, 85 (6): 335-343. 10.1111/j.0959-9673.2004.00401.x.
PubMed Central
PubMed
Google Scholar
Sakhuja P, Malhotra V: Nonalcoholic steatohepatitis--a histological perspective. Indian J Pathol Microbiol. 2006, 49 (2): 163-172.
PubMed
Google Scholar
Steen B: Maximizing outcome of dementia treatment: the role of nutrition. Arch Gerontol Geriatr Suppl. 2004, 413-417. 10.1016/j.archger.2004.04.063. 9
Alessenko AV, Bugrova AE, Dudnik LB: Connection of lipid peroxide oxidation with the sphingomyelin pathway in the development of Alzheimer's disease. Biochem Soc Trans. 2004, 32 (Pt 1): 144-146. 10.1042/BST0320144.
CAS
PubMed
Google Scholar
Laviad EL, Albee L, Pankova-Kholmyansky I, Epstein S, Park H, Merrill AH, Futerman AH: Characterization of ceramide synthase 2: tissue distribution, substrate specificity, and inhibition by sphingosine 1-phosphate. J Biol Chem. 2008, 283 (9): 5677-5684. 10.1074/jbc.M707386200.
CAS
PubMed
Google Scholar
Shah C, Yang G, Lee I, Bielawski J, Hannun YA, Samad F: Protection from high fat diet-induced increase in ceramide in mice lacking plasminogen activator inhibitor 1. J Biol Chem. 2008, 283 (20): 13538-13548. 10.1074/jbc.M709950200.
PubMed Central
CAS
PubMed
Google Scholar
Summers SA: Ceramides in insulin resistance and lipotoxicity. Prog Lipid Res. 2006, 45 (1): 42-72. 10.1016/j.plipres.2005.11.002.
CAS
PubMed
Google Scholar
Tong M, de la Monte SM: Mechanisms of ceramide-mediated neurodegeneration. J Alzheimers Dis. 2009, 16 (4): 705-714.
PubMed Central
PubMed
Google Scholar
Adibhatla RM, Hatcher JF: Altered Lipid Metabolism in Brain Injury and Disorders. Subcell Biochem. 2008, 48: nihpa41041
Google Scholar
Katsel P, Li C, Haroutunian V: Gene expression alterations in the sphingolipid metabolism pathways during progression of dementia and Alzheimer's disease: a shift toward ceramide accumulation at the earliest recognizable stages of Alzheimer's disease?. Neurochem Res. 2007, 32 (4-5): 845-856. 10.1007/s11064-007-9297-x.
CAS
PubMed
Google Scholar
Nakane M, Kubota M, Nakagomi T, Tamura A, Hisaki H, Shimasaki H, Ueta N: Lethal forebrain ischemia stimulates sphingomyelin hydrolysis and ceramide generation in the gerbil hippocampus. Neurosci Lett. 2000, 296 (2-3): 89-92. 10.1016/S0304-3940(00)01655-4.
CAS
PubMed
Google Scholar
Weiland D, Mondon CE, Reaven GM: Evidence for multiple causality in the development of diabetic hypertriglyceridaemia. Diabetologia. 1980, 18 (4): 335-340. 10.1007/BF00251016.
CAS
PubMed
Google Scholar
Wang XP, Ding HL: Alzheimer's disease: epidemiology, genetics, and beyond. Neurosci Bull. 2008, 24 (2): 105-109. 10.1007/s12264-008-0105-7.
PubMed
Google Scholar
Lijinsky W, Reuber MD, Riggs CW: Dose response studies of carcinogenesis in rats by nitrosodiethylamine. Cancer Res. 1981, 41 (12 Pt 1): 4997-5003.
CAS
PubMed
Google Scholar
Lijinsky W, Saavedra JE, Reuber MD: Induction of carcinogenesis in Fischer rats by methylalkylnitrosamines. Cancer Res. 1981, 41 (4): 1288-1292.
CAS
PubMed
Google Scholar
Bansal AK, Bansal M, Soni G, Bhatnagar D: Protective role of Vitamin E pre-treatment on N-nitrosodiethylamine induced oxidative stress in rat liver. Chem Biol Interact. 2005, 156 (2-3): 101-111. 10.1016/j.cbi.2005.08.001.
CAS
PubMed
Google Scholar
Clapp NK, Craig AW, Toya RE: Diethylnitrosamine oncogenesis in RF mice as influenced by variations in cumulative dose. Int J Cancer. 1970, 5 (1): 119-123. 10.1002/ijc.2910050116.
CAS
PubMed
Google Scholar
Siegmund KD, Connor CM, Campan M, Long TI, Weisenberger DJ, Biniszkiewicz D, Jaenisch R, Laird PW, Akbarian S: DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons. PLoS One. 2007, 2 (9): e895-10.1371/journal.pone.0000895.
PubMed Central
PubMed
Google Scholar
Budovsky A, Muradian KK, Fraifeld VE: From disease-oriented to aging/longevity-oriented studies. Rejuvenation Res. 2006, 9 (2): 207-210. 10.1089/rej.2006.9.207.
CAS
PubMed
Google Scholar
Goldman R, Shields PG: Food mutagens. J Nutr. 2003, 133 (Suppl 3): 965S-973S.
CAS
PubMed
Google Scholar
Liu WB, Liu JY, Ao L, Zhou ZY, Zhou YH, Cui ZH, Yang H, Cao J: Dynamic changes in DNA methylation during multistep rat lung carcinogenesis induced by 3-methylcholanthrene and diethylnitrosamine. Toxicol Lett. 2009, 189 (1): 5-13. 10.1016/j.toxlet.2009.04.022.
CAS
PubMed
Google Scholar
Iizuka S, Suzuki W, Tabuchi M, Nagata M, Imamura S, Kobayashi Y, Kanitani M, Yanagisawa T, Kase Y, Takeda S, Aburada M, Takahashi KW: Diabetic complications in a new animal model (TSOD mouse) of spontaneous NIDDM with obesity. Exp Anim. 2005, 54 (1): 71-83. 10.1538/expanim.54.71.
CAS
PubMed
Google Scholar
Figueroa CD, Taberner PV: Pancreatic islet hypertrophy in spontaneous maturity onset obese-diabetic CBA/Ca mice. Int J Biochem. 1994, 26 (10-11): 1299-1303. 10.1016/0020-711X(94)90099-X.
CAS
PubMed
Google Scholar
Myers SR, Ali MY: Haemoglobin adducts as biomarkers of exposure to tobacco-related nitrosamines. Biomarkers. 2008, 13 (2): 145-159. 10.1080/13547500701470561.
CAS
PubMed
Google Scholar
Chen GJ, Xu J, Lahousse SA, Caggiano NL, de la Monte SM: Transient hypoxia causes Alzheimer-type molecular and biochemical abnormalities in cortical neurons: potential strategies for neuroprotection. J Alzheimers Dis. 2003, 5 (3): 209-228.
PubMed
Google Scholar
Inokuchi J: Insulin resistance as a membrane microdomain disorder. Yakugaku Zasshi. 2007, 127 (4): 579-586. 10.1248/yakushi.127.579.
CAS
PubMed
Google Scholar
Han MS, Park SY, Shinzawa K, Kim S, Chung KW, Lee JH, Kwon CH, Lee KW, Park CK, Chung WJ, Hwang JS, Yan JJ, Song DK, Tsujimoto Y, Lee MS: Lysophosphatidylcholine as a death effector in the lipoapoptosis of hepatocytes. J Lipid Res. 2008, 49 (1): 84-97. 10.1194/jlr.M700184-JLR200.
CAS
PubMed
Google Scholar
Holland WL, Knotts TA, Chavez JA, Wang LP, Hoehn KL, Summers SA: Lipid mediators of insulin resistance. Nutr Rev. 2007, 65 (6 Pt 2): S39-46. 10.1111/j.1753-4887.2007.tb00327.x.
PubMed
Google Scholar
Kraegen EW, Cooney GJ: Free fatty acids and skeletal muscle insulin resistance. Curr Opin Lipidol. 2008, 19 (3): 235-241. 10.1097/01.mol.0000319118.44995.9a.
CAS
PubMed
Google Scholar
Pylypiw HM, Zubroff JR, Magee PN, Harrington GW: The metabolism of N-nitrosomethylaniline. J Cancer Res Clin Oncol. 1984, 108 (1): 66-70. 10.1007/BF00390975.
CAS
PubMed
Google Scholar
Singer GM, Taylor HW, Lijinsky W: Liposolubility as an aspect of nitrosamine carcinogenicity: quantitative correlations and qualitative observations. Chem Biol Interact. 1977, 19 (2): 133-142. 10.1016/0009-2797(77)90026-6.
CAS
PubMed
Google Scholar